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“Cavities are a communicable disease, and if you’re among the 90 percent of Americans who’s ever had one, you probably got them from your mother.”So begins “The Rise and Impending Fall of the Dental Cavity,” a remarkably engrossing and, for me, genuinely eye-opening survey of the history and science of tooth decay, published last week by the pseudonymous Cremieux Recueil on his Substack. The bacterium Streptococcus mutans might not seem like the likeliest subject for a 7,600-word general-interest deep-dive, but Cremieux takes detours into the immaculate teeth of dinosaurs, the practice of Neolithic dentistry, the agricultural and industrial revolutions and their effect on our diets, and the dental agony of America’s founding fathers. Probably, you remember admonitions from childhood that eating candy will rot your teeth, but that story turns out to be a bit simplistic — the problem isn’t that your teeth hate sugar but that Streptococcus mutans loves it. And when it consumes sugar, the byproduct is lactic acid, which is what really starts to eat away at your dental enamel. Not everyone has an oral microbiome dominated by Streptococcus mutans, but chances are if you do, it was passed to you by your parents, very early on — and if you eat any sugar, you’re very likely to suffer tooth decay.
Persons: who’s, , Recueil, Cremieux, Streptococcus mutans
The rare find could help scientists further understand how changes in the human diet have led to the prevalence of cavities today. Uncovered during two excavations from 1993 and 1996, the teeth were among several human teeth and other remains found within a limestone cave in County Limerick in Ireland. One tooth had a surprising abundance of Streptococcus mutans (S. mutans), an oral bacteria that causes cavities. Researchers also believe the bacteria is not as commonly found within ancient teeth because the human diet included less refined sugar and fewer processed foods than are consumed today, Cassidy said. … ancient teeth can help us understand how the human oral microbiota (range of microorganisms) has evolved over time and the impact of these changes on human health in the past and today,” Humphrey said in an email.
Persons: Lara Cassidy, Cassidy, mutans, , , would’ve, Tannerella, mutans “, Louise Humphrey, ” Humphrey Organizations: CNN, Trinity College Dublin Locations: County Limerick, Ireland, France, London
CNN —In a decision nearly five years in the making, the US Food and Drug Administration has decided that yogurts can now make a limited claim that the food may reduce the risk of type 2 diabetes, the federal agency concluded Friday. The decision marks the first-ever qualified health claim the federal agency has issued for yogurt. Qualified health claims “are supported by scientific evidence, but do not meet the more rigorous ‘significant scientific agreement’ standard required for an authorized health claim,” according to the FDA. The submission set in motion an FDA review of existing research on the relationships between yogurt and type 2 diabetes, according to a news release. Qualified health claims have been allowed by the FDA for dietary supplements since 2000 and for food since 2002, but they are rarely announced.
Persons: , Gurbuz, Streptococcus, Lisa Drayer Organizations: CNN, US Food and Drug Administration, FDA, , Getty, Danone North America
CHICAGO (AP) — The cause of death for a 5-year-old Venezuelan boy who died in December after becoming ill at a temporary shelter for migrants in Chicago was sepsis and a bacterial infection that causes strep throat, an autopsy released Friday shows. Jean Carlos Martinez died Dec. 17 as a result of sepsis due to streptococcus pyogenes group A infection, which can cause strep throat and other life-threatening illnesses, the autopsy released by the Cook County Medical Examiner's Office showed. Contributing factors in his death were listed as COVID-19, adenovirus and rhinovirus, the autopsy showed. The boy was a resident at a warehouse retrofitted as a shelter in Chicago’s Pilsen neighborhood when he suffered a medical emergency, the city has said. Earlier this month, hundreds of asylum-seekers still awaited placement at airports and police stations in Chicago, some of them still camped on sidewalks outside precinct buildings.
Persons: Jean Carlos Martinez Organizations: CHICAGO, Cook Locations: Chicago, Cook County, Chicago’s Pilsen, U.S, Texas
Ohio public health officials announced an outbreak of pneumonia in children on Wednesday. Experts say the Ohio outbreak is unrelated to pneumonia outbreaks in China and Europe. Although pneumonia cases are rising in Ohio, experts say the number of cases isn't out of the norm. AdvertisementCases of pneumonia in children are increasing in Ohio, leading public health officials to declare an outbreak. Health officials in Ohio said that there is "zero evidence" that the Ohio outbreak is connected to other outbreaks of respiratory illness nationally or internationally.
Persons: , pneumoniae, Clint Koenig Organizations: Service, Health District, World Health Organization, Children, Centers for Disease Control, ABC News, Warren, Warren County Health District Locations: Ohio, China, Europe, Warren, Denmark, Netherlands, lockdowns, Warren County
“RSV season is in full swing,” Cohen told the House Energy and Commerce Subcommittee on Oversight and Investigations. Respiratory virus activity is especially high in the Southern and Western US. The pathogens involved include adenovirus, Streptococcus pnuemoniae and Mycoplasma pneumoniae, bacteria that have been linked to a rising number of respiratory infections in China. Respiratory virus season is especially affecting children. Hospitalizations for respiratory viruses – including Covid-19, flu and RSV – have been on the rise for months.
Persons: Mandy Cohen, ” Cohen, , “ We’re, ” Covid, “ Covid, Cohen, it’s, pnuemoniae, Dr, Sanjay Gupta Organizations: CNN, US Centers for Disease Control, House Energy, , CDC, CNN Health, Prevention Locations: Southern, Western, Warren County, Ohio, China
CNN —Hospitals in northern China and Beijing have reported a surge in the number of children with respiratory illnesses, including pneumonia. Why might there be a surge in respiratory illnesses? CNN: How concerning is the spike in respiratory illnesses being reported in China? Dr. Leana Wen: Thus far, based on what we know from WHO, I don’t think the spike in respiratory illnesses should cause global concern. It’s very possible that other areas, especially those with previously strict virus mitigation measures, will see a rise in respiratory illnesses this winter.
Persons: Leana Wen, Wen, It’s, , it’s Organizations: CNN, World Health Organization, George Washington University Milken Institute School of Public Health, WHO, People's, Wen, US Centers for Disease Control Locations: China, Beijing, Fuyang, Covid, United States
Antimicrobial resistance (AMR), which the World Health Organization has referred to as the "silent pandemic," is an often overlooked and growing global health crisis. Sakis Mitrolidis | Afp | Getty ImagesMaking matters worse, research has shown that climate change is exacerbating the AMR crisis in several ways. "AMR bacteria is known as a silent pandemic. Extreme heat is fueled by the climate crisis, which makes extreme weather more frequent and more intense. "We hear people talking about this 'silent pandemic,' but it shouldn't be silent.
Persons: Sakis Mitrolidis, Tina Joshi, Joshi, University of Plymouth Robb Butler, Butler, Plymouth's Joshi Organizations: Planck, Biology, Getty, World Health, United, AMR, WHO, Afp, University of Plymouth, CNBC, UN, United Arab Emirates, Polygiene, Aircraft, Bloomberg, Plymouth's Locations: United Nations, Sikorahi, Alexandroupoli, Greece, WHO Europe, United Arab, UAE, Hamburg, Germany
Some group A Strep bacteria are resistant to these antibiotics,” according to Dr. Kristina Bryant, a pediatric infectious disease physician at Norton Children’s Hospital in Louisville. The precautions many people took to protect themselves from Covid-19, like wearing masks and social distancing, also protected them from strep throat. “Strep throat is a routine infection, and we know that cases are going to go up every year,” she said. If your child’s strep throat doesn’t get better with antibiotics, Bryant says, it may be that other bacteria in the throat are making the antibiotics less effective. “If the strep infection goes untreated, that individual can potentially be contagious with strep for weeks,” she said.
Persons: Amoxicillin, Kristina Bryant, Jennifer Stevenson, , “ Strep, ” Stevenson, Bryant, , hasn’t, Dr, Sanjay Gupta, Stevenson, McPhillips, Brenda Goodman Organizations: CNN, US Food, FDA, Norton Children’s Hospital, US Centers for Disease Control, Epic Research, Henry Ford Medical Center, CDC, Rapid, CNN Health Locations: Louisville, Dearborn , Michigan, Covid
Pfizer on Wednesday said its experimental vaccine targeting the potentially deadly bacterial disease Group B Streptococcus returned strong mid-stage clinical trial results, a promising step as the drug inches toward potential approval. Pfizer is among several drugmakers racing to develop the world's first shot targeting Group B strep disease, which is linked to nearly 150,000 infant deaths worldwide each year, especially in lower-income countries. Pfizer's single-dose shot generated antibodies that may provide infants with meaningful protection against the disease, according to the data released Wednesday from a phase two clinical trial. Pfizer's encouraging phase two trial results provide hope that maternal vaccination against the disease, also known as GBS, could help prevent thousands of cases in babies. The results will also help the company plan its phase three clinical trials on the shot, which are typically required before the FDA approves a drug.
Persons: Streptococcus, Melinda Gates Organizations: Pfizer, Drug Administration, FDA, Melinda Gates Foundation
Its peak sales forecast is of more than $2 billion annually together from the maternal vaccine and an RSV shot for older adults. The case highlights how equitable global access will require better advance planning by drugmakers, governments and health organizations, health officials say. "They could have tried sooner," said Erin Sparrow, WHO's technical officer for the RSV vaccine, referring to Pfizer. Pfizer has yet to take a number of steps needed to make the vaccine available in developing countries, according to global health officials and the company. She still expects it to be several years before the RSV vaccine is launched in lower-income countries.
US FDA approves Pfizer's next-generation pneumococcal vaccine
  + stars: | 2023-04-28 | by ( ) www.reuters.com   time to read: +1 min
April 28 (Reuters) - The U.S. Food and Drug Administration (FDA) has approved Pfizer Inc's (PFE.N) next-generation vaccine to prevent pneumococcal disease in children aged six weeks to 17 years, the company said late on Thursday. The vaccine, Prevnar 20, offers more protection against the disease versus the company's widely-used Prevnar 13 vaccine, by targeting seven more serotypes of the streptococcus pneumoniae bacteria that causes those infections. The pneumococcal disease can lead to infections in several parts of the body including the lungs, where they can cause pneumonia. The approval is based on results from mid-stage and late-stage studies that showed the vaccine's safety and tolerability was similar to Prevnar 13. Reporting by Sriparna Roy in Bengaluru; Editing by Subhranshu SahuOur Standards: The Thomson Reuters Trust Principles.
Its peak sales forecast is of more than $2 billion annually together from the maternal vaccine and an RSV shot for older adults. The case highlights how equitable global access will require better advance planning by drugmakers, governments and health organizations, health officials say. "They could have tried sooner," said Erin Sparrow, WHO's technical officer for the RSV vaccine, referring to Pfizer. Pfizer has yet to take a number of steps needed to make the vaccine available in developing countries, according to global health officials and the company. She still expects it to be several years before the RSV vaccine is launched in lower-income countries.
Group A Streptococcus (GAS) is the name for bacteria that can cause infections like strep throat, scarlet fever and impetigo. However, the 2014 study examined different bacteria and found that while their numbers increased following the nasal flu vaccine, that did not lead to increased bacterial disease. A recent UK study has also found that while infections of influenza itself be linked to increased cases of Group A Strep, the nasal vaccine is associated with a reduction in bacterial infections. But it did not investigate group A strep bacteria; rather, the study investigated Streptococcus pneumoniae and Staphylococcus aureus, which Mina said in an email, are “very different” pathogens to group A strep. A 2014 study does not show the nasal spray flu vaccine causes Group A Strep.
"And we know that measles, mumps and rubella vaccination coverage for kindergarteners is the lowest it has been in over a decade," Peacock said. Nearly a quarter of a million kindergartners are potentially vulnerable to measles due to a dip in vaccination coverage during the pandemic, according to the Centers for Disease Control and Prevention. Kindergarteners are required to be vaccinated against measles, mumps and rubella, chickenpox, polio, and diphtheria, tetanus and pertussis. The vaccination rates for measles, mumps and rubella was 93.5% during the 2021-2022 school year, below the target coverage of 95% to prevent outbreaks. The CDC report looked at whether the kindergarteners had received the second dose of their measles, mumps and rubella vaccine.
This winter, health officials have warned of what has been dubbed a tripledemic of influenza, RSV and continued COVID-19 cases, adding to the pressure on over-burdened health services. In Wales, for instance, there were 111.6 confirmed RSV cases per 100,000 in children aged under five in the week ending Nov. 27. In the week ended Dec 18, European cases rose 7% over the week prior, according to ECDC figures. But scientists are concerned that social interaction during the festive season could lead to further increases in respiratory infections, especially as people meet vulnerable elderly relatives. As an added complication, viral respiratory infections can predispose patients to bacterial infections, just when some common antibiotics that can treat them are in short supply in Europe.
Strep A is surging in the UK and has killed at least 19 kids, the UK Health Security Agency said. A vaccine would be better, but research groups have hit roadblocks during its development. Researchers have been trying to make a strep-A vaccine for decadesIf it's caught in time, strep A can be treated with antibiotics. There is no vaccine commercially available, but several research groups are working on developing one. A GSK spokesperson confirmed to Insider that it's also in the early stages of developing a strep-A vaccine but that it had not started human testing.
In the U.K., at least 15 children have died from invasive group A strep since mid-September. Anyone can get invasive strep A, including healthy adults, but people over 65 and those with chronic illnesses are more susceptible. Between 1,500 and 2,300 people die of the invasive infections every year. But children's hospitals in several other states — California, New York, Illinois and Minnesota — said they have not detected any increase in invasive group A strep. It is important for kids with strep to get care right away so they can start taking antibiotics like penicillin.
“The LAIV vaccine used in the UK does not contain Streptococcus A,” an MHRA spokesperson told Reuters via email. The bacteria are not listed in the ingredients for Fluenz Tetra (bit.ly/3HesXo4), which is also marketed in the U.S. as fluMist. “Group A strep is not used at any stage of the development of the nasal flu vaccine. The vaccine does not contain Group A strep,” Pollard said via email. The MHRA and AstraZeneca told Reuters that group A strep is not an ingredient in the Fluenz Tetra vaccine, and two independent experts said there are no reports of contamination.
Halfpoint Images | Moment | Getty ImagesHealth officials in the U.K. are warning parents to be alert after a recent spate of Strep A infections resulted in the deaths of at least six children. The U.K.'s Health Security Agency issued a rare health warning Friday urging parents to monitor their children for tell-tale symptoms of the illness, which can include a sore throat, headache, fever, and body rashes. While most cases are mild and often go unnoticed, it can also lead to more serious illness and complications, such as scarlet fever. Scarlet fever is a highly contagious bacterial infection that mostly affects young children. Make sure you talk to a health professional if your child is showing signs of deteriorating after a bout of scarlet fever.
London CNN —Health officials in the United Kingdom are advising parents and schools to watch for Strep A infections following the recent deaths of six children. While there is no vaccine to prevent Strep A or iGAS infections, antibiotics are usually effective at treating them. The increase in iGAS this year has particularly been observed in children under 10, the UKHSA added. For children aged 5 to 9, there were 1.1 cases per 100,000, compared with the pre-pandemic average of 0.3. The last period of high infections was between 2017 to 2018, with four children under 10 dying in the equivalent period, the statement added.
Заботливые родители не позволяют детям ковырять в носу, и стараются обучить свое чадо другим, более эстетичным, способам очищения. По словам британских специалистов, ковыряние в носу является опасной для здоровья привычкой, так как может стать причиной распространения пневмонии. Например, одним из известных возбудителей пневмонии – является Legionella pneumophila. Чтобы тщательнее изучить проблему был проведен эксперимент, участниками которого стали здоровые люди, готовые контактировать с возбудителями пневмонии. В результате стало ясно, что больше всего шансов заразиться у тех, кто ковыряет в носу — заражение происходит в 40% случаев.
Organizations: Школа тропической медицины Locations: Ливерпуль
Anual, pe data de 12 noiembrie este marcată Ziua Mondială de prevenire a Pneumoniei, scopul căreia este sensibilizarea opiniei publice în privința pneumoniei. Pneumonia este o boală infecțioasă care provoacă inflamația alveolelor pulmonare (denumiți și „saci respiratori”) a unuia sau a ambilor plămâni. Pneumonia este cel mai mare ucigaș infecțios al adulților și al copiilor, ce a luat viața a peste 2,5 milioane de oameni, inclusiv 672.000 de copii în anul 2019. În total, pentru grupul de vârstă de 0 – 17 ani în anul 2019 au decedat 52 copii, față de 55 în 2018. Reducerea poluării aerului diminuează riscul de apariție a pneumoniei severe la copii;6.
Persons: Pandemia, Potrvit, OMS, Imunizarea Organizations: UNICEF Locations: Republica Moldova pneumonia, Diareii
Pe parcursul anului trecut, 52 de copii au murit din cauza pneumoniei. Cei mai mulți – 49 de copii – aveau vârstele cuprinse între 0 și 5 ani (36 de copii până la un an). Specialiștii atenționează că în Republica Moldova pneumonia este o problemă importantă de sănătate publică, caracterizată de indicatori destul de înalți ai morbidității și mortalității, îndeosebi la copiii de până la cinci ani. Datele sunt prezentate de către Agenția Națională pentru Sănătate Publică în contextul Zilei mondiale de prevenire a pneumoniei, marcată pe 12 noiembrie, transmite IPN. Pentru a preveni pneumonia, specialiștii recomandă alăptarea exclusivă în primele șase luni de viață, practică ce poate reduce incidența pneumoniei cu 23%.
Persons: Pandemia Organizations: Agenția Națională Locations: Republica Moldova pneumonia, pneumonia
Primul om care a primit Premiul Nobel pentru Pace a fost fondatorul Crucii Roșii, elvețianul Henri Dunant în 1901. Din 1901, premiul a fost acordat unui număr total de 213 de cercetători, dintre care doar trei au fost femei. Mecanismul a fost numit Crispr/Cas9 și a fost supranumit „foarfecele genetic”. Este angajată a Institutului de Medicină Howard Hughes și membră Academiei de Științe și a Academiei de Medicină din SUA. Din 1901, premiul a fost acordat, în total, de 111 ori, iar 184 de oameni de știință au devenit laureați ai acestuia.
Persons: Nobel, Pace, Antonio, PAM, SUA Dwight D . Eisenhower, Henri Dunant, Theodore Roosevelt, Martin Luther King, german Willie Brandt, SUA Henry Kissinger, Teresa, SUA Barack Obama, Roger Penrose, Reinhard Genzel, Andrea Ghez, Max Planck, . Penrose, Albert Einstein, Sir Roger Penrose, Stephen Hawking, Wilhelm, Nielson Bohr, Marie Curie, Pierre Curie, Antoine Henri Becquerel, franceze Emmanuelle Charpentier, Jennifer Doudna, Emmanuelle Charpentier, Medicină Howard Hughes, Jacobus, van’t, Maria, Curie, Harvey J ., Michael Houghton, Charles M . Rice, virusologul Harvey J ., Chiron, Houghton, american Charles M . Rice, Louis, Emil Adolf von Bering, Ronald Ross, Robert Koch, Ivan Pavlov, Frederick Banting, John McLeod, Alexander Fleming, Ernest Chain, Howard Florey, Louise Glück, Glück, Anders Ohlsson, Sarah Lawrence, Rudyard Kipling, Doris Lessing, Bob Dylan ., Svetlana Aleksievici, Paul R ., Robert B . Wilson, Stanford . Robert B . Wilson, Paul R . Milgrom, Milgrom, Wilson, Alfred Nobel, Jan Tinbergen, Ragnar Frisch Organizations: Universitatea din, Națiunilor Unite, ONU, Organizația, Organizația ONU, Crucii Roșii, Regale, franceze, Science, Academiei, Științe, Academiei Naționale, Medicină, Academiei de Științe, Academiei de Medicină, maimuțelor, Universitatea St, Organizației Mondiale a Sănătății, Academia Suedeză, Nobel, Academia suedeză, Universității Columbia ., Academiei Americane, Academiei Poeților, Universitatea Yale ., Universitatea Stanford, Stanford ., Universității Harvard, Stanford Business School, Banca Centrală, Academiei Regale Locations: Stockholm, Universitatea din Oslo, Roma, ONU, Republica Democrată Congo, Nigeriei, Sudanul de Sud, Siria, Yemen, german, SUA, Universitatea din Oxford, Germania, Universitatea din California, Berkeley, Los Angeles, Regatului Unit, Franța, Olanda, Universitatea din Alberta, Canada, american, Washington, americană, New York, maghiară, Yale, Boston, Iowa, engleză
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